Gimme a brake: HPK1 regulates LFA-1 and neutrophil traction.
نویسنده
چکیده
In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase 1 (HPK1) participates during signaling of neutrophil recruitment by acting as a regulator of the adhesiveness of the b2-integrin lymphocyte function-associated antigen 1 (LFA-1) during acute inflammation.
منابع مشابه
Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1-mediated neutrophil recruitment during the acute inflammatory response.
Recruitment of polymorphonuclear neutrophils (PMNs) to sites of acute inflammation critically depends on β2 integrins (CD11/CD18). Recently, the mammalian actin-binding protein 1 (mAbp1) was identified as an important adaptor protein regulating PMN trafficking downstream of β2 integrins. Here, we show that mAbp1 constitutively co-immunoprecipitated with hematopoietic progenitor kinase 1 (HPK1) ...
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T cells that express a constitutively activated form of the integrin LFA-1 (bottom) have restricted mobility compared to those expressing wild-type LFA-1 (top). show that immune cells expressing a perpetually activated form of the integrin LFA-1 get traction at the front of the cell, but get stuck from behind. Their lagging ends prevent them from crawling through the endothelium and initiating ...
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1 University of California, Davis. Department of Biomedical Engineering. Genome and Biomedical Sciences Facility, 451 E. Health Sciences Dr., Davis, California, 95616-5294. 530-752-1430 (U. S., A. F. H. L., M. R. S.) 530-754-2193 (C. E. G.), 530-752-0299 (S. I. S.). Fax 530-754-5739 2 ICOS Corporation, 22021 20 Ave. SE, Bothell, Washington 98021. 3 Current Address: The Scripps Research Institut...
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BACKGROUND Hematopoietic progenitor kinase 1 (HPK1) is a Ste20-related serine/threonine kinase activated by a range of environmental stimuli including genotoxic stress, growth factors, inflammatory cytokines and antigen receptor triggering. Being inducibly recruited to membrane-proximal signalling scaffolds to regulate NFAT, AP-1 and NFkappaB-mediated gene transcription in T-cells, the function...
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Hematopoietic progenitor kinase 1 (HPK1) regulates stress responses, proliferation, and apoptosis in hematopoietic cells. In this study, we examined the expression, regulation, and functions of HPK1 in pancreatic ductal adenocarcinomas (PDA). We found that loss of HPK1 protein expression correlated significantly with the progression of pancreatic intraepithelial neoplasias (P = 0.001) and devel...
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عنوان ژورنال:
- Blood
دوره 121 20 شماره
صفحات -
تاریخ انتشار 2013